Abstract:Objective To investigate the effect of arthroscopic excision of popliteal cysts via double posteromedial portals with the body position of the Chinese character of “4” on knee function and inflammatory indexes.Methods Clinical data of 70 patients with popliteal cysts from January 2019 to October 2021 were retrospectively analyzed, and classified into two groups. The observation group (n = 36) received arthroscopic excision of popliteal cysts via double posteromedial portals with the body position of the Chinese character of “4”, the control group (n = 34) received traditional surgery, thereafter, the pre-and post- operative inflammatory indexes, Lysholm knee function score and Japanese Orthopedic Association (JOA) score were compared between the two groups.Results Serum levels of interleukin-6 (IL-6), interleukin-8 (IL-8), C-reactive protein (CRP), Lysholm score and JOA score before the surgery showed no significant difference between the two groups (P > 0.05). At postoperative 48 h, the levels of IL-6, IL-8 and CRP of observation group were significantly lower than those of control group (P < 0.05), and Lysholm score and JOA score of observation group were higher than those of control group (P < 0.05). The postoperative complication rate was 5.56% in observation group, which was significantly lower than 23.53% in control group (P < 0.05). Compared with control group, observation group had significantly lower intraoperative blood loss, with statistical difference (P < 0.05), shorter first out-of-bed activity time and hospital stay length (P < 0.05).Conclusion Application of arthroscopic excision of popliteal cysts via double posteromedial portals with the body position of the Chinese character of “4” can effectively promote the functional recovery and alleviate the inflammation responses in patients.