内镜黏膜下剥离术在早期胃癌患者中的长期疗效研究

Long-term effect of endoscopic submucosal dissection in patients with early gastric cancer

摘要:

目的 探索内镜黏膜下剥离术（ESD）和外科手术对早期胃癌患者长期疗效的影响。方法 回顾性分析2016年11月－2018年3月该院早期胃癌患者的临床资料，根据治疗方式不同分为两组，观察组（n = 46）行ESD，对照组（n = 46）行外科手术治疗。结果 观察组手术时间和住院时间较对照组短，术中出血量和住院费用较对照组少，两组患者比较，差异有统计学意义（P < 0.05）。两组患者1、2和3年生存率比较，差异无统计学意义（P > 0.05）。两组患者1、2和3年复发率比较，差异无统计学意义（P > 0.05）。观察组并发症总发生率为4.35%，明显低于对照组的19.57%，两组患者比较，差异有统计学意义（P < 0.05）。结论 与外科手术相比，对早期胃癌患者实施ESD，手术时间和住院时间短，患者出血量少，创伤小，术后并发症发生风险低，有助于提高患者预后，具有较好的治疗效果。

Abstract:

Objective To explore the effects of endoscopic submucosal dissection (ESD) and surgery on the long-term efficacy of patients with early gastric cancer.Methods Retrospective analysis of the clinical data of patients with early gastric cancer from November 2016 to March 2018 was divided into two groups according to the different treatment methods. The control group (n = 46) treated with surgery, the observation group (n = 46) underwent ESD.Results Operation time and hospitalization time in the observation group were significant shorter than those in control group , intraoperative blood loss and hospitalization expenses in the observation group were significant less than those in the control group. There was no significant difference in the 1-year, 2-year and 3-year survival rates between the two groups (P > 0.05). There was no significant difference in the recurrence rate between the two groups in the 1-year, 2-year and 3-year (P > 0.05). The total incidence of complications in the observation group was 4.35%, significantly lower than 19.57% of the control group, the difference was statistically significant (P < 0.05).Conclusion Compared with surgical operation, ESD for patients with early gastric cancer has shorter operation time and hospital stay, less bleeding and trauma, and lower risk of postoperative complications, which improves the prognosis of the patient and has a good therapeutic effect.