纳米碳淋巴结示踪技术结合腹腔镜微创手术在结直肠癌患者中的应用

Application of nanocarbon lymph node tracing technology combined with laparoscopic minimally invasive surgery in patients with colorectal cancer

摘要:

目的 分析纳米碳淋巴结示踪技术结合腹腔镜微创手术在结直肠癌患者中的应用。方法 选取2015年4月－2020年10月该院确诊的结直肠癌患者76例，采用随机分组法分为观察组和对照组，各38例。观察组在肿瘤周围黏膜下层注射纳米碳淋巴结示踪剂后，行腹腔镜结直肠癌根治手术；对照组直接行腹腔镜结直肠癌根治手术。记录两组患者淋巴结检出和转移情况，并记录观察组不同直径淋巴结的黑染和转移率情况，比较两组患者术中、术后相关指标和并发症发生情况。结果 观察组淋巴结检出数、转移阳性淋巴结数目、直径5 mm以下淋巴结数目和转移阳性淋巴结数目明显多于对照组（P < 0.05）。观察组直径3 mm以下的淋巴结黑染率明显高于直径3 mm以上的淋巴结（P < 0.05）；观察组黑染淋巴结转移率明显高于未黑染淋巴结（P < 0.05）。两组患者手术情况和术后恢复情况比较，差异均无统计学意义（P > 0.05）；观察组并发症发生率明显低于对照组（P < 0.05）。结论 纳米碳淋巴结示踪技术结合腹腔镜微创技术，可以提高淋巴结检出数量和发现阳性转移淋巴结，不增加手术复杂程度，并降低并发症发生率，利于患者术后恢复。

Abstract:

Objective To analyze the application of nanocarbon lymph node tracing technology combined with laparoscopic minimally invasive surgery in patients with colorectal cancer.Methods 76 patients confirmed with colorectal cancer were enrolled between April 2015 and October 2020. They were divided into observation group and control group by random grouping method, 38 cases in each group. The observation group underwent laparoscopic radical colorectal cancer surgery after injection of nanocarbon lymph node tracer into peritumoral submucosa, while control group underwent laparoscopic radical colorectal cancer surgery directly. The detection and metastasis of lymph nodes in the two groups, black staining of lymph nodes with different sizes and metastasis rate of lymph nodes in observation group, intraoperative and postoperative recovery in both groups, and postoperative complications were recorded.Results The number of detected and metastasis-positive lymph nodes, and number of lymph nodes shorter than 5 mm and metastasis-positive lymph nodes in observation group were significantly more than those in control group (P < 0.05). In observation group, black staining rate of lymph nodes with diameter less than 3 mm was significantly higher than that of lymph nodes with diameter more than 3 mm (P < 0.05), and metastasis rate of black-staining lymph nodes was significantly higher than that without black-staining (P < 0.05). There was no significant difference in operation and postoperative recovery between the two groups (P > 0.05). The incidence of complications in observation group was significantly lower than that in control group (P < 0.05).Conclusion Nanocarbon lymph node tracing technology combined with laparoscopic minimally invasive surgery can increase the number of detected lymph nodes and find metastasis-positive lymph nodes, which can not increase surgical complexity and reduce the incidence of complications, be beneficial to postoperative recovery.