Abstract:Objective To study the efficacy and safety of endoscopic sclerotherapy and prolapse and hemorrhoidectomy (PPH) in treatment of internal hemorrhoids.Methods Medical records of 100 patients with internal hemorrhoids from March 2015 to August 2020 were retrospectively screened. According to the different groups, they were treated with Lauromacrogol injection under colonoscopy, and the PPH group was treated with stapled prolapse and hemorrhoid circumcision, respectively. Over the following 6 months, the clinical efficacy, postoperative complications, recurrence rate, average length of stay and cost were observed between the two groups.Results The total effective rate of treatment was 94.0% and 88.0% respectively, in the sclerotherapy group and in the PPH group. There was no statistically significant difference between the two groups (P > 0.05). The sclerotherapy group's average stays and expenses of hospitalization, and patient satisfaction were significantly better than those of the PPH group, and the postoperative pain was significantly less than that of the PPH group. The differences were statistically significant (P < 0.05). The total incidences of complications in the sclerotherapy group were 8.0%, which was significantly less than the 32.0% in the PPH group. There was statistically difference in the complication (P < 0.05).Conclusion Endoscopic sclerosing agent injection for internal hemorrhoids is simple to operate, quick to recover, safe, effective and worthy of clinical application.