Abstract:Objective To explore the clinical value of three approaches for endoscopic resection of cholesteatoma in the middle ear.Methods clinical data of 203 patients underwent middle ear cholesteatoma resection from January 2010 to December 2019 were retrospectively analyzed. Among them, The concept of "lock hole" and the surgical technique of absorption microscope were used in 88 ears of 85 cases, the middle ear cholestatoma was removed by endoscopic surgical approach through three surgical approaches: external auditory meatus-attic-tympanum-mastoidprocess, external auditory meatus-tympanum-mastoid process and auricular vessel incision-tympanum-mastoid process, and 121 ears of 118 cases received radical mastoid surgery under microscope. Surgical complications and postoperative recurrence were compared between the two groups.Results The mean postoperative follow-up period was 6~24 months. Between the endoscopic group and the microscopic group, there were no statistically significant differences in dry ear rate (94.32 vs 95.87%), surgical complication rate (10.23% vs 12.40%), residual and recurrent rate (6.82% vs 4.13%).Conclusion Endoscopic ear surgery can remove cholesteatoma of the middle ear involving the entire mastoid process through three approaches, expanding the scope of surgical treatment of cholesteatoma of the middle ear.