Abstract:Objective To investigate the advantages, efficacy and safety of suture of the mucosal defects after colorectal endoscopic submucosal dissection under single forceps endoscopy with metal clips pulled by floss.Methods A retrospective analysis was performed on 17 patients who used dental floss traction assisted metal clamping to suture the wounds after ESD operation from June 2018 to September 2020 through single forceps endoscope, among of them, 2 cases of ileocecal region, 2 cases of ascending colon, 3 cases of transverse colon, 3 cases of descending colon, 3 cases of sigmoid colon and 4 cases of rectum. The size of the wound after ESD, the time of wound sealing, the success rate, the incidence of postoperative complications and the results of colonoscopy were observed.Results The diameter of the wounds after ESD was 3.0~6.5 cm, and among them, 16 cases were sutured satisfactorily with a success rate of 94.1%, and in one case, only part of the wound was sutured due to premature cutting of floss and failure of traction. The time of suturing the wound was 5~16 min. No delayed bleeding and perforation occurred in all cases. 3~24 months after operation, reexamination of enteroscopy showed that the metal clips on the wound fell off and the wound recovered well.Conclusion It is simple, safe and practical to suture the wound after colorectal ESD with clips pulled by floss.