Abstract:Objective To evaluate the clinical value of Pituitrin combined with cervical ligation in laparoscopic subtotal hysterectomy.Method 249 cases on which laparoscopic subtotal hysterectomy were performed from January 2014 to January 2019, were divided into three groups. The routine group of 73 cases (group A): removed parauterine tissue and open peritoneal fold of bladder and rectum, then electrocoagulate uterine artery and vein beside cervix; The cervical ligation group of 83 cases (group B): ligated uterine artery and vein in the middle of the baring cervix with Roeder's coil made by absorbable line; The Pituitrin combined with cervical ligation group of 93 cases (group C): 6 u Pituitrin diluted with 20 mL normal saline was injected into the uterus, after the contraction of the blood vessels of the uterus, the operation was performed according to group B. The operative time, operative blood loss, postoperative exhaust time, postoperative total peritoneal drainage and postoperative hemoglobin decrease were observed and compared among the three groups.Results The operative time, intraoperative blood loss, postoperative exhaust time, postoperative total peritoneal drainage and postoperative hemoglobin decrease in group B and C were better than those in group A, the intraoperative blood loss and postoperative hemoglobin decrease in group C were better than those in group B, the differences were statistically significant (P < 0.05). The operative time, postoperative exhaust time and postoperative total peritoneal drainage between the group B and C were not statistically significant (P > 0.05). All the 249 patients in the three groups were followed up for three months, all the patients recovered well.Conclusion The laparoscopic subtotal hysterectomy with Pituitrin and cervical ligation can shorten the operative time, reduce operative blood loss and accelerate the recovery of patients, simplify the complicated operation, make the high-risk operation safely and effectively reduce the incidence of various accessory injury.