乙酰半胱氨酸在胶囊内镜检查中的临床应用

Clinical application of acetylcysteine in capsule endoscopy

摘要:

目的 探讨胶囊内镜（CE）检查前应用乙酰半胱氨酸对CE小肠清洁度及检查结果的影响。方法 将150例行CE检查的患者随机分为观察组和对照组（各75例）。对照组在检查前1晚使用复方聚乙二醇电解质散（PEG）3 000 mL行肠道准备；观察组在检查前1天给予乙酰半胱氨酸600 mg口服（1天3次），检查前1晚使用PEG 3 000 mL行肠道准备。两组CE检查前30 min均口服二甲硅油散，比较两组患者的小肠清洁度、CE在小肠内停留时间、小肠疾病阳性检出率和不良反应发生率。结果 两组患者CE在小肠停留时间、不良反应发生率和阳性检出率比较，差异均无统计学意义（P > 0.05）；观察组小肠清洁度明显高于对照组，两组比较，差异有统计学意义（P < 0.05）。结论 CE检查前服用乙酰半胱氨酸具有提高小肠清洁度的作用，且不良反应小，值得临床推广。

Abstract:

Objective To investigate the effect of small bowel cleansing quality and examination results of capsule endoscopy with acetylcysteine before the procedure.Methods 150 patients scheduled for capsule endoscopy were randomly divided into observation group and control group (75 cases in each group). Patients in control group received a preparation with 3 000 mL compound polyethylene glycol electrolyte the evening before the procedure; Patients in observation group followed the control group and were administered 600 mg acetylcysteine the day before the procedure with 3 times a day. All the patients were requested to ingest dimethicone powder 30 min prior to capsule ingestion. Comparing the small bowel cleansing quality, small bowel transit time, positive rate and the incidence of adverse reactions between the two groups.Results There were no statistically significant differences in small bowel transit time, the incidence of adverse reactions and positive rate between the two groups (P > 0.05). The cleanliness of small bowel in the observation group was significantly higher than that in control group, and the difference was statistically significant (P < 0.05).Conclusion Taking acetylcysteine before capsule endoscopy can improve small bowel cleansing quality. And the adverse reactions are minor, which is worthy of clinical promotion.