Abstract:Objective To discuss the safety tolerance of the sedation and analgesia gastroscope and the acceptability of the subject by comparing the application effect of sedation and analgesia gastroscope and general gastroscope in clinical examination.Methods The patients who participated in the screening of upper gastrointestinal from May 2019 to August 2019 were selected as the research object, and the gastroscopy method was selected according to the willingness of the subjects. Then compare the changes of relevant signs before and after examination between the two groups, and analyze the application effect of sedation and analgesia gastroscopy.Results The difference in systolic blood pressure, heart rate and blood oxygen saturation before and after examination in sedation and analgesia gastroscopy group was statistically significant (P < 0.05); The difference between the systolic blood pressure and heart rate before and after examination in general gastroscopy group was statistically significant (P < 0.05); There was no statistically significant difference in blood pressure, heart rate and blood oxygen saturation before examination between the two groups (P > 0.05); The systolic blood pressure and heart rate in the sedation and analgesia gastroscopy group were lower than those in general gastroscopy group, and the difference was statistically significant (P < 0.05); The incidence of adverse reactions (cough, salivation, restlessness, nausea and vomiting, sore throat) in sedation and analgesia gastroscopy group was lower than that of general gastroscopy group (P < 0.05). The tolerance degree and satisfaction in sedation and analgesia gastroscopy group were significantly better than general gastroscopy group (P < 0.05); The sedation and analgesia gastroscopy group had a significantly higher rate of forgetting the examination process than the general gastroscopy group(P < 0.05); The difference in the detection rate of positive lesions between the two groups was statistically significant(2.98% vs 0.47%, χ2 = 4.42, P = 0.036).Conclusion The sedation and analgesia gastroscopy method the subject is more tolerable, and the incidence of adverse reactions is low, the detection rate of positive lesions is high, which is more conducive to the examination of patient-related lesions, and the subject's satisfaction and acceptance of the examination are higher.