Abstract:Objective To investigate the clinical safety and efficacy of percutaneous nephrolithotomy combined with electronic pyeloscope or choledochoscopy and retrograde intrarenal surgery in treatment of staghorn calculi.Methods Retrospective analysis of clinical data of 203 patients with staghorn calculi within 4 cm from December 2013 to December 2018, including electronic pyeloscope or choledochoscopy combined with percutaneous nephrolithotomy group (n = 122) and simple retrograde intrarenal surgery group (n = 81). Baseline data such as age, gender, stone size, and BMI value of each group were counted, and the perioperative data of each group were compared.Results There were no statistically significant differences between the two groups, such as operative time, complication rate and hospitalization expenses. However, the difference was significant statistical between the two groups in first-stage stone clearance rate, hospitalization time and the third-party patient satisfaction.Conclusion The percutaneous nephrolithotomy combined with retrograde intrarenal surgery in treatment of staghorn calculi within 4 cm has the characteristics of high clearance rate of patients in the first stage and high patient satisfaction, retrograde intrarenal surgery have the advantage of quick recovery after surgery.