Abstract:Objective To compare the merits and demerits of vaginal natural orifice transluminal endoscopic surgery (V-NOTES) and transumbilical laparoendoscopic single-site surgery (TU-LESS) in myomectomy.Methods Sufferring from single leiomyoma in the anterior wall of the uterus, 23 patients who underwent V-NOTES (observation group) and 44 patients who underwent TU-LESS (control group) were enrolled in the study from January 2019 to October 2019. The operation time, intraoperative hemorrhage volume, postoperative anal exhaust time, pain scale at the first day after surgery (NRS digital grading score), postoperative hospital stay, postoperative mean peak body temperature and hospitalization costs were compared.Results The postoperative anal exhaust time was shorter in the observation group (25.52 ± 4.17) h than that in the control group (32.72 ± 3.06) h (P < 0.05); The NRS pain score at the first day after operation of the observation group (2.65 ± 0.98) score was lower than that in control group (4.50 ± 1.00) score (P < 0.05); There were no significant difference in the operation time, intraoperative hemorrhage volume, postoperative hospital stay, postoperative mean peak body temperature and hospitalization cost between the two groups (P > 0.05).Conclusion Vaginal natural orifice transluminal endoscopic surgery is feasible in the treatment of single leiomyoma in the anterior wall of the uterus. The recovery time of gastrointestinal function is shorter, the pain is lighter, and it is worth promoting.