谐波造影增强超声内镜诊断胰腺癌的Meta分析

Contrast-enhanced harmonic endoscopic ultrasound in diagnosis of pancreatic carcinoma: a Meta-analysis

摘要:

目的 评价谐波造影增强超声内镜技术对胰腺癌的诊断价值。方法 通过检索PubMed、Embase和Cochrane图书馆等数据库，收集有关谐波造影增强超声内镜技术诊断胰腺实性病变的相关文献，按照纳入和排除标准进行筛查，提取数据，并进行方法学质量评价。采用Stata软件计算谐波造影增强超声内镜诊断胰腺癌的合并敏感性（SE）和特异性（SP），绘制森林图及综合受试者工作特征曲线（SROC），计算曲线下面积（AUC），并探讨异质性程度和来源。结果 最终纳入15项研究，共1 693例患者，合并SE为0.91（95%CI：0.87～0.94），合并SP为0.79（95%CI：0.71～0.85），SROC AUC为0.93（95%CI：0.90～0.95）。结论 谐波造影增强超声内镜对胰腺癌有良好的诊断效能。

关键词:谐波造影增强超声内镜;胰腺癌;Meta分析

Abstract:

Objective To evaluate the diagnostic value of contrast-enhanced harmonic endoscopic ultrasound (CEH-EUS) in pancreatic carcinoma.Methods Studies on CEH-EUS for the assessment of pancreatic carcinoma were searched in PubMed, EMBASE, and the Cochrane Library. The documents were screened according to the inclusion and exclusion criteria. Then evaluate the quality of the included studies. The sensitivity (SE) and specificity (SP) were calculated by Stata software. Forest plots and a summary receiver operating characteristic (SROC) curve were drawn, and the area under the curve (AUC) were calculated. Explore the degree and source of heterogeneity.Results A total of 15 studies and 1 693 patients were included, the combined SE was 0.91 (95%CI: 0.87~0.94), SP was 0.79 (95%CI: 0.71~0.85), SROC AUC was 0.93 (95%CI: 0.90~0.95).Conclusion CEH-EUS is effective in the diagnosis of pancreatic cancer.

Key words:contrast-enhanced harmonic endoscopic ultrasound;pancreatic carcinoma;Meta-analysis