内镜窄带成像技术联合放大内镜诊断胃癌准确性的Meta分析
作者:
作者单位:

1.西南医科大学临床医学院,四川 泸州 646000;2.四川绵阳四〇四医院 消化中心, 四川 绵阳 621000

作者简介:

] 唐榛在四川绵阳四〇四医院规培
文黎明为四川绵阳四〇四医院消化内科主任

通讯作者:

文黎明,E-mail:wenlm404@sohu.com;Tel:13320893860

基金项目:

2020年四川省卫生健康委员会科研课题(No:20PJ269)


Diagnostic accuracy of magnifying endoscopy with narrow-band imaging in gastric cancer: a Meta-analysis
Author:
Affiliation:

1.Clinical Medical College, Southwest Medical University, Luzhou, Sichuan 646000, China;2.Department of Gastroenterology, Sichuan Miangyang 404 Hospital, Miangyang, Sichuan 621000, China

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    摘要:

    目的 探讨放大内镜联合窄带成像技术(ME-NBI)对胃癌的诊断价值。方法 全面检索Web of Science、Cochrane Library、PubMed、万方数据库、中国知网和维普中文数据库的相关文献,年限为建库至2019年12月,利用Meta-Disc 1.4和Stata 15.0软件进行Meta分析。结果 最终纳入34篇文献,包括7 255例胃癌患者和7 711处病灶。Meta分析结果显示:ME-NBI诊断胃癌准确性的合并灵敏度(SE)为0.87(95%CI:0.85~0.89);特异度(SP)为0.96(95%CI:0.96~0.97);约登指数(YI)为0.83;阳性似然比(LR+)为10.91(95%CI:7.16~16.61);阴性似然比(LR-)为0.15(95%CI:0.11~0.20);诊断优势比(DOR)为82.61(95%CI:46.64~146.31);综合受试者工作特征曲线(SROC)下面积(AUC)为0.95(95%CI:0.93~0.97)。结论 ME-NBI对胃癌有较高的诊断价值,为胃癌诊断的重要手段,可指导临床工作。

    Abstract:

    Objective To explore the diagnostic value of magnifying endoscopy with narrow-band imaging (ME-NBI) in gastric cancer.Methods We searched relevant literatures of Web of Science, Cochrane Library, PubMed, WanFang databases, CNKI and VIP databases comprehensively (up to December 2019). Meta-Disc 1.4 software and Stata 15.0 software were used for meta analysis.Results 34 studies with a total of 7 255 gastric cancer patients and 7 711 lesions were included in the present analysis. Pooled sensitivity of ME-NBI to diagnose gastric cancer is 0.87 (95%CI: 0.85 ~ 0.89); Pooled specificity of ME-NBI to diagnose gastric cancer is 0.96 (95%CI: 0.96 ~ 0.97); Youden index is 0.83; Positive likelihood ratio (LR+) is 10.91 (95%CI: 7.16 ~ 16.61); Negative likelihood ratio (LR-) is 0.15 (95%CI: 0.11 ~ 0.20); Diagnostic Odds Ratio (DOR) is 82.61 (95%CI: 46.64 ~ 146.31); Area under SROC curve (AUC) is 0.95 (95%CI: 0.93 ~ 0.97).Conclusion ME-NBI has a high diagnostic value for gastric cancer, which can be used as an important measure for diagnosis of gastric cancer and guide clinical work.

    表 2 纳入文献质量评价结果Table 2 Quality assessment of included literatures
    表 3 纳入文献的基线特征Table 3 Basic characteristics of included literatures
    表 1 亚组分析结果Table 1 The outcomes of the subgroup analysis
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  • 收稿日期:2020-03-12
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  • 在线发布日期: 2021-01-08