Abstract:Objective To compare the patients comfort and physicians difficulty and the procedure time during transnasal fiberoptic laryngoscopy after single nasal topical anesthesia or naso-oro topical anesthesia.Methods This study included 1 300 patients randomizely divided into group A (single nasal topical anesthesia, n = 650) and group B (naso-oro topical anesthesia, n = 650). Feeling scores (0~10) was used to evaluate patient tolerance and procedure success by the operator, independently. Procedure time was also recorded. Then, we made a subgroup analysis according to the preliminary diagnosis of laryngeal malignant tumor.Results There was no significant difference in the examination time between the two groups. Both patients’ and doctors’ scores were significantly higher in group A. There was no significant difference in feeling scores between the two groups. There was no significant difference in procedure time between the two groups.Conclusion Single nasal topical anesthesia seems to be superior to naso-oro topical anesthesia in patients undergoing uncomplicated laryngoscopy, if the patient can't endure the procedure, additional naso-oro topical anesthesia should be given then. Naso-oro topical anesthesia seems to be not superior to single nasal topical anesthesia in patients underwent complicated laryngoscopy, doctors should try to find better anesthesia methods.