自固定补片与生物补片对成人腹股沟疝腹腔镜术后炎症因子及并发症的影响

Comparison on effects of automatic-fixation patch and biological patch on inflammatory factors and complications in the adult with inguinal hernia after laparoscopic surgery

摘要:

目的 探讨自固定补片与生物补片对成人腹股沟疝（IH）腹腔镜术后炎症因子和并发症的影响。方法 选取2017年1月－2019年9月该院收治的IH患者80例，随机分为对照组和观察组，每组各40例。对照组给予生物补片治疗，观察组给予自固定补片治疗。比较两组手术情况、术前与术后第1天外周血炎症因子水平［C-反应蛋白（CRP）、白细胞介素-10（IL-10）和白细胞介素-6（IL-6）］、术前与术后第1、7和15天视觉模拟评分（VAS）、术后6个月并发症和复发情况。结果 观察组手术时间和术中出血量明显少于对照组，两组比较，差异有统计学意义（P < 0.05）；两组住院时间比较，差异无统计学意义（P > 0.05）。术后第1天，观察组IL-6和CRP水平明显低于对照组，两组比较，差异有统计学意义（P < 0.05）；两组IL-10水平比较，差异无统计学意义（P > 0.05）。观察组术后第1、7和15天VAS评分明显低于对照组，两组比较，差异有统计学意义（P < 0.05）。两组术后6个月并发症发生率比较，差异无统计学意义（P > 0.05），两组均无复发。结论 与生物补片相比，腹腔镜术中使用自固定补片治疗成人IH可以减少术中出血量、缩短手术时间、减轻术后炎症反应，有效缓解疼痛，不增加并发症发生率和复发率，安全性较高。

Abstract:

Objective To explore effects of automatic-fixation patch and biological patch on inflammatory factors and complications in the adult with inguinal hernia (IH) after laparoscopic surgery.Methods 80 IH patients from January 2017 to September 2019 were randomly divided into control group and observation group, 40 cases in each. The control group was treated with biological patch, while observation group was treated with automatic-fixation patch. The operation condition, levels of inflammatory factors in peripheral blood [C-reactive protein (CRP), interleukin-10 (IL-10), interleukin-6 (IL-6)] at 1st day before and after surgery, visual analogue scale (VAS) before surgery, at 1st day, 7th day and 15th day after surgery, complications and recurrence within 6 months after surgery were compared between the two groups.Results The operation time and intraoperative blood loss in observation group were significantly lower than those in control group (P < 0.05). There was no significant difference in hospitalization time between the two groups (P > 0.05). The levels of IL-6 and CRP at 1st day after surgery in observation group were significantly lower than those in control group (P < 0.05), while there was no significant difference in IL-10 level between the two groups (P > 0.05). The VAS scores at 1st, 7th and 15th day after surgery in observation group were significantly lower than those of control group (P < 0.05). There was no significant difference in incidence of complications within 6 months after surgery between the two groups (P > 0.05). There was no recurrence in either group.Conclusion Compared with biological patch, application of automatic-fixation patch in treatment of IH adults in laparoscopic surgery can reduce intraoperative blood loss, shorten operation time, alleviate postoperative inflammatory response, effectively relieve pain, and not increase incidence of complications and recurrence rate, with high safety.