Abstract:Gallbladder preservation surgery has a history of more than 100 years. However, the previous surgeries had not been popularized because they suffered from a high recurrence rate. Instead, a new minimally invasive surgery of choledochoscopic gallbladder-preserving cholecystolithotomy is capable of removing all stones in a gallbladder, treating the lesions of the gallbladder wall, and ensuring the unblocked cystic duct. At present, many hospitals in China and foreign countries have carried out such gallbladder preservation surgery with satisfactory clinical results. It has been confirmed that it is a safe, reliable, and simple surgical operation with a low recurrence rate which was less than 10.00%. Moreover, the gallbladder function recovers quickly after the operation. However, the efficacy of this operation still requires long-term clinical observation. We also suggest future research may utilising machine learning and other artificial intelligence to compare the data of the studied patients to an extensive established database, so that maximize the chance of successfully achieving the goals of the surgery.