综合规范治疗联合功能性内镜鼻窦手术对中、重度无息肉型慢性鼻-鼻窦炎疗效及复发率的影响

Clinical efficacy of the combination therapy with comprehensive standard treatment and functional endoscopic sinus surgery on moderate and severe polypoid-free chronic rhinosinusitis

摘要:

目的 分析综合规范治疗联合功能性内镜鼻窦手术对中、重度无息肉型慢性鼻-鼻窦炎疗效及复发率的影响。方法 选取2017年1月－2018年9月大连大学附属中山医院收治的中、重度无息肉型慢性鼻-鼻窦炎患者92例，采用随机数字表法将所有患者均分为对照组（n = 46）和观察组（n = 46），对照组行功能性内镜鼻窦手术治疗，观察组行综合规范治疗联合功能性内镜鼻窦手术治疗。两组药物治疗方案一致。对两组临床治疗效果和复发率进行比较。结果 两组患者治疗前鼻腔鼻窦结局评分和鼻内镜评分比较，差异均无统计学意义（P > 0.05），两组治疗后6和12个月均较治疗前明显改善，差异有统计学意义（P < 0.05），且观察组均优于对照组，两组比较，差异有统计学意义（P < 0.05）；两组治疗前嗅觉功能比较，差异无统计学意义（P > 0.05），观察组治疗后12个月优于对照组，两组比较，差异有统计学意义（P < 0.05）；两组治疗满意度和复发率分别为95.65%、4.35%和86.96%、13.04%，观察组均优于对照组，两组比较，差异有统计学意义（P < 0.05）。结论 综合规范治疗联合功能性内镜鼻窦手术治疗中、重度无息肉型慢性鼻-鼻窦炎，能够取得理想的治疗效果且复发率低，值得临床推广使用。

Abstract:

Objective To analyze the efficacy and recurrence rate of comprehensive standard treatment combined with functional endoscopic sinus surgery on moderate and severe polypoid-free chronic rhinosinusitis.Methods 92 patients with moderate or severe polypoid-free chronic rhinosinusitis from January 2017 to September 2018 were randomly divided into functional endoscopic sinus surgery. 46 patients in the control group and the comprehensive standard treatment combined with functional endoscopic sinus surgery were treated with the same drug treatment. The clinical treatment effect and recurrence rate were compared between the two groups.Results There were no significant differences in nasal sinus scores and nasal endoscopy scores between the two groups before treatment (P > 0.05). There was a statistically significant difference between the 6 months after treatment and the 12 months after treatment (P <0.05), the comparison between the groups was better than the control group, there was statistical difference (P < 0.05); there was no statistical difference between the two groups before treatment (P >0.05), 12 months after treatment the observation group was superior to the control group, and there was statistical difference (P < 0.05). The satisfaction and recurrence rates of the two groups were 95.65%, 4.35%, and 86.96%, 13.04%, respectively. The observation group was superior to the control group, there was statistical difference (P < 0.05).Conclusion Comprehensive standard treatment combined with functional endoscopic sinus surgery in the treatment of moderate and severe polypoid-free chronic rhinosinusitis can achieve the desired therapeutic effect and low recurrence rate, which is worthy of popularization.