Abstract:Abstract: Objective?To evaluate the feasibility, safety and efficacy of tubeless mini-percutaneous nephrolithotomy (MPCNL) under local anesthesia.?Methods?Clinical data of 133 cases received tubeless MPCNL under local anesthesia were summarized retrospectively. All the cases were compared respectively with 145 cases who received standard MPCNL.?Results?All the patients successfully received tubeless MPCNL under the local anesthesia. Of the 133 patients, 28 patients had total tubeless MPCNL. The mean visual analog scale (VAS) of tubeless MPCNL under the local anesthesia in operation was (3.8?±?3.0). The difference in the stones size, operation time, stone free rate and complications among the two groups were not statistically significant (P?>?0.05). While the fluctuation of BP in operation, postoperative visual analog pain scale scores, analgesia requirement and postoperative hospitalization days of tubeless MPCNL under the local anesthesia were statistically significant (P?0.05) compared with the standard MPCNL. During the 3 to 40 monthes follow-up period, no obviously urinous extravasation and perinephric urinary cyst occured in all patients, and the puncture passages were all accreted well.?Conclusions?Tubeless MPCNL handled under local anesthesia was simple safe and effective for the indication patients, it showed less pain, shorter hospital stay, deserved clinical popularizing use.