Abstract:Abstract: Objective?To evaluate the feasibility, safety and efficacy of tubeless mini-percutaneous nephrolithotomy (MPCNL) under local anesthesia.?Methods?Clinical data of 133 cases received tubeless MPCNL under local anesthesia were summarized retrospectively. All the cases were compared respectively with 145 cases who received standard MPCNL.?Results?All the patients successfully received tubeless MPCNL under the local anesthesia. Of the 133 patients, 28 patients had total tubeless MPCNL. The mean visual analog scale (VAS) of tubeless MPCNL under the local anesthesia in operation was (3.8?±?3.0). The difference in the stones size, operation time, stone free rate and complications among the two groups were not statistically significant (P?>?0.05). While the fluctuation of BP in operation, postoperative visual analog pain scale scores, analgesia requirement and postoperative hospitalization days of tubeless MPCNL under the local anesthesia were statistically significant (P?