内镜下抗反流黏膜切除术治疗难治性胃食管反流病初探

Preliminary results of anti-reflux mucosectomy in treatment of refractory gastroesophageal reflux disease

摘要:

摘要：目的??探讨内镜下抗反流黏膜切除术（ARMS）治疗难治性胃食管反流病（RGERD）的初步疗效及安全性。方法 回顾性分析2017年6月－2019年1月宁波市第一医院6例行ARMS治疗的RGERD患者的临床资料，治疗前后行反流症状指数（RSI）、胃食管反流病健康相关生存质量量表（GERD-HRQL）及吞咽困难评分，评价治疗的疗效。结果 全组6例患者均顺利完成内镜下ARMS术，无术中术后穿孔、出血等严重并发症。术后随访至少6个月，最长至26个月。术后1个月RSI评分及GERD-HRQL评分为（9.7±3.9）和（11.3±2.3）分，与术前比较，差异均有统计学意义（P??0.05），术后6个月无1例患者存在吞咽困难[评分为（0.0±0.0）分]，与术前比较，差异有统计学意义（P?

Abstract:

Abstract: Objective?To evaluate the safety and efficacy of endoscopic anti-reflux mucosectomy (ARMS) for refractory gastroesophageal reflux disease.?Methods?6 patients who underwent anti-reflux mucosectomy from June 2017 to January 2019 were enrolled in this study, and the clinical data were analyzed retrospectively. RSI, GERD-HRQL and dysphagia scores were used before and after the operation for evaluation of curative effect of anti-reflux mucosectomy.?Results?6 patients underwent anti-reflux mucosectomy successfully. No major adverse events such as perforation or bleeding was found in perioperative period. The patients were followed up for at least 6 months, and the longest follow-up time was up to 26 months. RSI and GERD-HRQL scores were (9.7?±?3.9) and (11.3?±?2.3) respectively one month after ARMS (P??0.05), but no patients felt dysphagia 6 months after ARMS [The score is (0.0±0.0), P?