Abstract:Abstract: Objective?To observe and compare the clinical efficacy and safety of transforminal and interlaminar approaches of percutaneous endoscopic lumbar discectomy (PELD) in treatment of single-segment degenerative lumbar spinal stenosis (DLSS).?Methods?A retrospective analysis was performed on 32 patients who underwent PELD for single-segment DLSS, from April 1st 2017 to April 1st 2018. Twenty cases were treated by transforminal (TF) approach and 12 patients underwent interlaminar (IL) approach. We compared the numerical rating scale (NRS) and improved Oswestry disability index (ODI) between the two groups, as well as the operation time, number of fluoroscopy, complications, costs, satisfaction, and so on.?Results?The postoperative NRS and ODI of patients in the two groups were lower than preoperation (P?0.05). However, there were no significant difference in NRS, ODI, operation time, complications and satisfaction between the two groups (P?>?0.05).?Conclusion?PELD can effectively treat single-segment DLSS.