Abstract:Abstract: Objective?To explore the clinical value of endoscopic autologous blood injection for localization in colorectal disease before laparoscopic surgery.?Methods?21 patients with colorectal disease by endoscopic autologous blood injection for tumor localization from January 2016 to December 2018 were analyzed retrospectively.?Results?Of 20 cases (95.2%) completed autologous blood injection for localization under colonoscope successfully, the dark red marks were clearly during the operation, there were no complication such as perforation, bleeding, infection and fever. 1 case (4.8%) had bloodstain in abdominal cavity under laparoscopy accompanied by mild abdominal pain, no fever or peritonitis were found. All of the 21 patients were successfully completed the laparoscopic surgery with negative margin postoperative pathology.?Conclusion?Autologous blood injection under endoscopy is safe, simple and effective localization method, satisfactory effect of localization can be obtained before operation, it is worthy of clinical application.