Abstract:Abstract: Objective?To compare the clinical efficacy of foraminoscopic nerve root decompression and nucleus pulposus enucleation with interlaminar fenestration in treatment of unilateral lumbar disc herniation (LDH). ?Methods?98 patients with unilateral LDH were divided into two groups by random number table method (n?=?49). Group A underwent foraminoscopic nerve root decompression and group B underwent interlaminar fenestration and nucleus pulposus enucleation. The operation condition, effect and improvement of low back pain were compared between the two groups.?Results?The operation time of group A was significantly longer than that of group B, the amount of bleeding during operation was significantly less than that of group B, and the length of incision, the time of getting out of bed and the days of hospitalization were significantly shorter than those of group B (P?0.05). The visual analogue score (VAS) of the two groups at 1 day, 3 months and 6 months after operation was significantly lower than that before operation, and there was no significant difference between the two groups (P?>?0.05). The JOA score of the two groups was significantly higher than that of the preoperative, and the ODI score of the three and six months after operation was significantly lower than that of the preoperative. There was no significant difference between the two groups in JOA score and ODI index (P?>?0.05). There was no significant difference between the two groups (P?>?0.05). There was no significant difference between the two groups (P?>?0.05).?Conclusion?Endoscopic nerve root decompression and release is as effective as interlaminar fenestration for unilateral LDH, but the former has less trauma, less bleeding, shorter hospital stays and faster recovery after operation.