链霉蛋白酶+西甲硅油+碳酸氢钠溶液配制后放置不同时间口服对胃镜检查质量的影响

Effect of oral administration of pronase + simethicone + sodium bicarbonate solution on the quality of gastroscopy

摘要:

摘要：目的??探讨链霉蛋白酶+西甲硅油+碳酸氢钠溶液配制后放置不同时间口服对胃镜检查质量的影响。方法 选取该院2018年11月－2019年4月行无痛胃镜的患者1?200例，随机分为4组，A组（n?=?300）：链霉蛋白酶+西甲硅油+碳酸氢钠溶液配置后立即口服；B组（n?=?300）：链霉蛋白酶+西甲硅油+碳酸氢钠溶液配置后放置1?h口服；C组（n?=?300）：链霉蛋白酶+西甲硅油+碳酸氢钠溶液配置后放置2?h口服；D组（n?=?300）：链霉蛋白酶+西甲硅油+碳酸氢钠溶液配置后放置3 h口服。4组患者均口服混合液60?mL，20?min后行无痛胃镜检查，对比分析4组患者胃镜视野清晰度及微小病灶发现率。结果 A组和B组胃镜视野清晰度及病灶发现率比较，差异无统计学意义（P?>?0.05）；A组和B组胃镜视野清晰度及病灶发现率明显优于C组和D组（P??0.05）。结论 链霉蛋白酶+西甲硅油+碳酸氢钠溶液配置后放置1?h内口服效果最佳，可以明显改善胃镜视野及提高微小病灶发现率，溶液放置2?h后口服，胃镜视野清晰度明显变差，微小病灶发现率明显降低。

Abstract:

Abstract: Objective?To investigate the effect of oral administration of pronase?+?simethicone?+?sodium bicarbonate solution on the quality of gastroscopy.?Methods?1?200 patients with painless gastroscopy from November 2018 to April 2019 were randomly divided into 4 groups. Group A (n?=?300): oral administration of pronase?+?simethicone?+?sodium bicarbonate solution; Group B (n?=?300): pronase?+?simethicone?+?sodium bicarbonate solution was placed and placed for 1 hour orally; Group C (n?=?300): pronase?+?simethicone?+?sodium bicarbonate solution and placed for 2 hours orally; Group D (n?=?300): pronase?+?simethicone?+?sodium bicarbonate solution was placed and placed orally for 3 hours. All the 4 groups of patients were given 60 ml of oral mixture, and painless gastroscopy was performed 20 minutes after oral administration. The visual field clarity and microscopic lesion discovery rate of the 4 groups were compared.?Results?There was no significant difference in the depth of visual field and the rate of lesions between the patients in group A and group B (P?>?0.05). The patients in group A and group B were significantly better than those in group C and D (P??0.05).?Conclusions?After pronase+simethicone+sodium bicarbonate solution, the best oral effect after 1 hour of placement can significantly improve the microscopic field of view to improve the discovery rate of microscopic lesions. After the solution is placed for 2 hours, the visual field clarity is obviously worse, and the rate of lesion discovery was significantly reduced.