Abstract:Abstract: Objective?To investigate the clinical application value of anatomical and programmed retroperitoneoscopic adrenalectomy by six-step procedure.?Methods?From July 2018 to September 2019, 50 patients with adrenal tumors treated were selected as the study subjects. They were divided into group A (25 cases) and group B (25 cases) by the random number table method. The methods used in group A and group B were respectively for transabdominal laparoscopic adrenalectomy and anatomical and programmed retroperitoneoscopic adrenalectomy by six-step procedure. The operation time, intraoperative blood loss, postoperative get out bed activity, postoperative intestinal function recovery time, visual analogue scale (VAS) for pain, postoperative drainage tube removal time, post-hospitalization time, the highest systolic blood pressure (SBP) and diastolic blood pressure (DBP) in the intraoperative removal of the adrenal gland, intraoperative complications (intestinal tube injury, pancreatic injury, hypertensive crisis, etc.) and the incidence of postoperative complications (incision infection, pulmonary infection, intestinal obstruction, hypertensive crisis, deep venous thrombosis of the lower extremities) for the two groups were compared.?Results?The intraoperative blood loss and postoperative drainage tube removal time between the two groups were no significant difference (P?>?0.05). The time of operation, postoperative get out bed activity, postoperative intestinal function recovery, postoperative hospital stay in group B were shorter than those in group A (P?0.05). The VAS pain score in group B was lower than those in group A (P?0.05). The range of volatility of the highest systolic blood pressure (SBP) and diastolic blood pressure (DBP) in the intraoperative removal of the adrenal gland in group B were lesser than those in group A (P?0.05). The incidence of postoperative complications between the two groups were no significant difference (P?>?0.05). The incidence of intraoperative complications in group B were lower than those in group A (P?0.05).?Conclusion?The anatomical and programmed retroperitoneoscopic adrenalectomy by six-step procedure is safe and effective in the treatment of adrenal tumors 6.00 cm in diameter. Intraoperative use of anatomical landmarks and avascular plane, sequential surgical operation, clear anatomical structure, early treatment of the adrenal central vein, post-processing the adrenal gland, is conducive to maintaining the stability of intraoperative hemodynamics, reducing the difficulty of postoperative laparoscopic surgery and perioperative surgical risk, thereby improving the clinical efficacy of patients.