Abstract:Abstract: Objective?To compare the clinical effiicacy and health economics between the transoral-vestibule endoscopic thyroidectomy (TOVET) and conventional open thyroidectomy (COT).?Methods?The clinical data of 80 patients with thyroid tumors underwent COT and TOVET from July 2016 to July 2018 were retrospectively collected. General data such as gender, age, tumor location, TI-RADS grading, as well as operative time, drainage tube, total postoperative drainage volume, drainage tube placement time, pain score, hospitalization time, and hospitalization expenses were observed and analyzed.?Results?There were significant differences in gender, age, and TI-RADS grading between the two groups (all P?0.05). The TOVET group had a slightly longer operative time than the COT group, and was superior in whether or not to place the drainage tube, postoperative drainage volume, drainage tube placement time, pain score, and hospitalization time. There was a statistically significant difference between the two groups (all P?0.05), but there was no significant difference in hospitalization costs between the two groups (P?>?0.05).?Conclusion?Young women prefer to choose TOVET, which is superior to COT in postoperative patient management, pain score, and hospitalization time, and does not significantly increase the patient’s hospitalization costs. It is safe and feasible, and produces an outstanding cosmetic effect. It is worthy of promotion and application.