Abstract:Abstract: Objective?To analyze the clinical efficacy of endoscopic injection of medical tissue gel “sandwich” and metal clamp in the treatment of peptic ulcer hemorrhage.?Methods?Retrospective analysis was conducted of the data of 102 patients with peptic ulcer hemorrhage treated under endoscope from October 2015 to June 2018. All the patients were divided into treatment group (56 cases) and control group (46 cases). The treatment group was treated with endoscopic medical tissue glue “sandwich” method, and the control group was treated with endoscopic metal clip to observe the rate of immediate hemostasis, rebleeding rate and adverse reaction rate.?Results?In the treatment group, the rate of hemostasis was significantly higher than that of the control group, and the rate of rebleeding was significantly lower than that of the control group, with statistical differences (P?0.05). There was no statistical difference in the incidence of ADR between the treatment group and the control group (P?>?0.05), and no deaths occurred.?Conclusion?Endoscopic injection of medical tissue glue “sandwich” is a safe and effective method for the treatment of peptic ulcer bleeding. The effect is accurate, and the survival rate of the patient is improved. It is worth clinical application.