Abstract:Abstract: Objective?To evaluate the efficacy and safety of endoscopic ligation for hemorrhoidal disease as a first-line invasive treatment.?Methods?This prospective study was conducted from Feburary 2017 to Feburary 2018 on 54 consecutive patients with grade II-III hemorrhoids. Endoscopic ligation was performed. Over the following 1 month, 6 months, 12 months, the improvement of symptoms, occurrence of complications and recurrence were observed. Clinical outcomes were evaluated using the visual analog scale (VAS) score for pain, French bleeding score, quality-of-life score and prolapse score.?Results?At 12 months after ligation, clinical success was obtained in 47 patients (87.0%), no patients experienced any serious complications.all indexes evaluated were decline significantly. VAS score decreased from (3.9?±?2.1) to (1.9?±?1.1) (P?=?0.012), and bleeding score decreased from (5.5?±?2.4) to (2.3?±?1.5) (P?=?0.000). Quality-of-life score decreased from (2.6?±?0.7) to (1.2?±?0.6) (P?=?0.039) and prolapse scores decreased from (2.4?±?0.5) to (1.6?±?0.6) (P?=?0.002), and recurrence were observed in 2 patients (3.7%), occurred after 10 and 11 month.?Conclusions?Endoscopic ligation was found to be a safe and effective treatment for hemorrhoids.