Abstract:Abstract: Objective?To evaluate the effect of local infiltration anesthesia with Ropivacaine on postoperative pain after laparoscopic single-site surgery and effect on ERAS.?Methods?From December 2017 to January 2019, 147 cases of gynecological patients who underwent laparoscopic single-site surgery were randomly and blindly divided into three groups. 49 cases received incision local infiltration anesthesia with Ropivacaine; 49 cases received the intravenous Flurbiprofen analgesia and 49 cases were the control group. Visual analogue scale (VAS) was used to evaluate the postoperative pain and analyze postoperative indicators.?Results?VAS pain score was significantly lower in the two groups using postoperative analgesia at 48 h after the operation than that in the control group (P?0.05). The incidence of postoperative nausea and vomiting and the average hospitalization cost of patients in the Ropivacaine incision group and the control group were lower than those in the Flubuprofen group (P?0.05). The time of getting out of bed, postoperative exhaust and hospitalization of the two groups of postoperative analgesia were lower than the control group (P?0.05). The incidence of postoperative nausea and vomiting and the average hospitalization cost of patients in incision local infiltration anesthesia group were not statistically different from those in the control group (P?>?0.05).?Conclusion?Local infiltration anesthesia with Ropivacaine after laparoscopic single-site surgery can reduce postoperative pain and facilitate ERAS, which is economical, safe and effective, and suitable for clinical application.