Abstract:Abstract: Objective?To evaluate the impact of preoperative sleep quality on Propofol dosage in elderly patients who underwent painless colonoscopy.?Methods?60 patients scheduled for painless colonoscopy, aged 65?~?76 years and with the American Society of Anesthesiologists (ASA) classification Ⅱ?~?Ⅲ grade, were recruited into the trial. Before the operation, the Pittsburgh Sleep Quality Index (PSQI) was used to diagnose the presence or absence of sleep disorders. Among them, PSQ?≥?5 was divided into sleep disorders; PSQI?5 was classified as normal sleep. Patients were divided into sleep disorder group and normal sleep group, 30 cases in each. Both groups received intravenous Oxycodone 0.05 mg/kg at 5 minutes before induction. The loading dose of Propofol 0.50?~?1.00?mg/kg was intravenously injected, and the anesthesia was maintained after the eyelash reflex disappeared as follows: intravenous pumping infusion of Propofol 3?~?5 mg/(kg·h). Propofol 0.5 mg/kg was added during the body motion reaction during the examination. The main observation was the amount of Propofol used during the operation. Secondary observation: intraoperative observer’s assessment of alertness/sedation (OAA/S) score; intraoperative respiratory depression, body motion response, abdominal pain, nausea and vomiting; induction time, recovery time, operation time; blood oxygen saturation decreased (SpO2 less than 95% and 90% respectively), and the time from the end of the examination to the time of entering the recovery room. Pain and weakness after colonoscopy were evaluated using visual analogue pain score (VAS) (0 to 10?cm). The indexes of postoperative gastrointestinal function were recorded in the two groups.?Results?Compared with the sleep disorder group, the dosage of Propofol used in the normal sleep group was significantly reduced (P?0.05). The number of cases in which the pulse oxygen saturation decreased by less than 95% and the number of oxygen saturation decreased by less than 90% were similar in both groups (P?>?0.05). Intraoperative OAA/S score, the rate of respiratory depression, physical activity, abdominal pain, nausea and vomiting during operation, and the time interval from the end of the examination to the recovery room and the VAS score were not significantly different between the two groups (P?>?0.05). Compared with the sleep disorder group, the wake-up time after colonoscopy was significantly shortened (P?0.05), and the postoperative pain score and the weakness was not significant (P?>?0.05). There was no statistical significance (P?>?0.05) in the indexes of postoperative gastrointestinal function.?Conclusion?Preoperative sleep disorders can effectively increase the dosage of Propofol in elderly patients who underwent painless colonoscopy and prolong the recovery of elderly patients.