Abstract:Abstract: Objective?To explore the short-term and long-term effects of arthroscopic joint debridement combined with Honghua Huayu Decoction in treatment of knee osteoarthritis and its effect on hemorheology.?Methods?120 patients with KOA admitted from January 2015 to January 2017 were divided into observation group and control group according to the random number remainder method. The observation group was treated with arthroscopic joint debridement combined with Honghua Huayu Decoction fumigation, the control group was treated with arthroscopic joint debridement, then compare the changes of hemorheology and the short-term and long-term effects of the two groups.?Results?The total effective rate of the observation group was higher than that of the control group (P?0.05). The degree of swelling of the knee joint was gradually relieved in the two groups. The difference was statistically significant between the two groups, at different time points (P?0.05). After treatment, the whole blood viscosity, plasma viscosity and erythrocyte aggregation index decreased (P?0.05), and the red blood cell deformation index increased (P?0.05), the difference between the two groups was statistically significant (P?0.05). After 2 years of follow-up, the osteoarthritis index score, joint mobility, maximum flexion, visual pain simulation score improved after the treatment, and the differences were statistically significant between the two groups, at different time points (P?0.05). No adverse reactions occurred in the two groups.?Conclusion?Arthroscopic joint debridement combined with Honghua Huayu Decoction fumigation has a positive effect on the improvement of hemorheology, adjustment of knee joint function and postoperative pain and swelling in KOA patients, which can fundamentally improve the short-term and long-term efficacy of KOA.