Abstract:Abstract: Objective?To investigate the therapeutic effect in treatment of large tympanic membrane perforation by endoscopic sandwiching myringoplasty.?Methods?Retrospective analysis from January 2017 to October 2017, 18 patients with 21 sides large perforation of tympanic membrane were subjected to endotoscopic tympanoplasty with Sandwiching, the operative duration and blood loss were statistically analyzed. The patients were followed up within 6 months after tympanoplasty, the condition of tympanic membrane was observed, and the preoperative and postoperative hearing conditions were compared.?Results?The average operative time was (44.95 ± 8.50) min, and the average operative blood loss was (19.19 ± 3.16) ml. 19 sides tympanic membrane completely healing, the success rate of tympanoplasty was 90.48%. 2 sides tympanic membrane was perforated again due to fungal infection after completely healing. Postoperative 6 month the mean airway auditory threshold and air-bone gaps were lower than those of preoperative, and the difference was statistically significant (P ﹤ 0.05).?Conclusions?The study suggested that endoscopic sandwiching of myringoplasty is a safe surgical method with high graft success and effective hearing reconstruction in large tympanic membrane perforation. It is worthy of clinical promotion.