胃食管反流病合并食管裂孔疝患者的临床特点分析

Clinical characteristics of patients with gastroesophageal reflux disease complicated with esophageal hiatal hernia*

摘要:

摘要：目的??分析胃食管反流病（GERD）合并食管裂孔疝（HH）患者的临床特点及其危险因素。方法?回顾性分析2018年1月－2019年3月在宁夏回族自治区人民医院消化内科诊断为GERD合并HH的40例患者并作为研究组，另外40例GERD未合并HH的患者为对照组，比较两组患者的基本临床资料、内镜分级、Barrett食管发生率。结果?研究组患者的年龄、体重、吸烟史、糖尿病与对照组比较，差异均有统计学意义（P <0.05），两组性别、饮酒史和冠心病比较，差异均无统计学意义（P >0.05）；研究组食管外症状较多见，内镜下分级仅有C级与对照组比较差异有统计学意义（P <0.05）；A级、B级、D级两组差异无统计学意义（P >0.05）；两组Barrett食管发生率比较，差异有统计学意义（P <0.05）。结论?GERD合并HH与年龄、体重、吸烟史、糖尿病有关，且其会使Barrett食管发生率升高，积极防控可改变的因素对该类患者可能有一定的好处。

Abstract:

Abstract: Objective?To analyze the clinical features and risk factors of patients with gastroesophageal reflux disease complicated with esophageal hiatal hernia.?Methods?From January 2018 to March 2019, 40 patients with gastroesophageal reflux disease complicated with esophageal hiatal hernia were included in the study group, and 40 patients with gastroesophageal reflux disease were not combined. Patients with esophageal stenosis were included in the control group. The basic clinical data, endoscopic grading, and incidence of Barrett’s esophagus were compared between the two groups.?Results?Compared with the control group, patients with gastroesophageal reflux disease complicated with esophageal hiatus hernia were associated with age, weight, smoking history, diabetes (P < 0.05), but not with gender, drinking history, coronary heart disease (P > 0.05); Compared with the control group, the extra-esophageal symptoms were more common in the study group, and only the C-grade was different in the endoscopic grade (P < 0.05), but the difference between the A, B, and D grades was not statistically significant (P > 0.05). There was a statistically significant difference in the incidence of Barrett’s esophagus between the two groups (P < 0.05).?Conclusion?Gastroesophageal reflux disease combined with esophageal hiatal hernia is related to age, weight, smoking history, diabetes, and it can lead to an increase in the incidence of Barrett’s esophagus. The factors that may be positively controlled may have certain benefits for this patient.