Abstract:【Objective】 To investigate the diagnostic efficacy of magnifying narrow-band imaging in distinguishing neoplastic from non-neoplastic small colorectal polyps, using NICE (NBI international colorectal endoscopy) classification system. 【Methods】 A total of 264 small colorectal polyps were enrolled in this study. Each lesion was observed by magnifying narrow-band imaging, and the histology was predicted according to NICE classification system. The results were compared with histologic findings. 【Results】 The diagnostic sensitivity, specificity, accuracy, PPV, and NPV of magnifying narrow-band imaging were 93.6% (102/109)、96.1% (149/155)、95.1% (251/264)、94.4% (102/108) and 95.5% (149/156), respectively. 【Conclusion】 NICE classification system with magnifying narrow-band imaging is effective in distinguishing neoplastic from non-neoplastic small colorectal polyps.