Abstract:To probe into the clinical application value of therapeutic effect of percutaneous transforaminal nucleus pulposus extraction on lumbar disc herniation under different anesthesia. Methods From January 2016 to December 2017, 110 patients with lumbar disc herniation were selected as clinical research subjects. The selected subjects were randomly divided into observation group (56 cases) and control group (54 cases) by random number table method. The patients with lumbar disc herniation in the two groups were treated with percutaneous transforaminal nucleus pulposus removal. The patients in the study group were treated with combination of lumbar and spinal anesthesia, and the patients in the control group were treated with intubation general anesthesia. The MoCA score, MMSE score, VAS score, ODI index and clinical treatment of the patients in the two groups were compared and analyzed. Results Compared with control group, the MoCA scores (28.25 ± 3.94) points and MMSE scores (29.72 ± 4.08) points in observation group after surgery were increased significantly higher than the control group, the differences were significant statistically (P < 0.05); The VAS scores (2.97 ± 0.40) points and the ODI index (20.54 ± 3.16)% after surgery in observation group were significantly lower than the control group, the differences were significant statistically (P < 0.05); The rate of clinical treatment 66.07% (37/56) and the total excellent rate 94.64% (53/56) after surgery in observation group were significantly higher than control group, the differences were significant statistically (P < 0.05). Conclusion Percutaneous transforaminal nucleus pulposus removal combined spinal and epidural anesthesia has positive and practical significance for the improvement of cognitive function, relief of pain symptoms and improvement of clinical treatment in patients with lumbar disc herniation.