Abstract:To investigate the effect of wrist and ankle acupuncture on Propofol dosage in painless gastroscopy. Methods 120 cases of patients, aged 70 ~ 85, ASA Ⅱ and stable condition ASA Ⅲ. According to the random number table, the patients were divided into the control group and the wrist-ankle acupuncture group, with 60 cases in the control group and 60 cases in the experimental group. The wrist and ankle acupuncture group received puncture and needle retention in the corresponding area before entering the room. After entering the room, the two groups were given intravenous nalbuphine 0.1 mg/kg, and the targeted intravenous infusion of Propofol was carried out gastroscopic operation when the eyelash reaction disappeared and the breath was inappropriate. Propofol was added as appropriate according to the intraoperative body movement. The total amount of Propofol, the operation time of gastroscopy, the time of waking up, the time of leaving the room, respiratory depression, hypotension, nausea and vomiting and other adverse reactions were recorded. Results The dosage of Propofol, time of waking up and time of leaving the room in the wrist and ankle acupuncture group were significantly lower than those in the control group (P < 0.05), and the incidence of respiratory depression, hypotension and postoperative nausea and vomiting was lower than those in the control group (P < 0.05). Conclusion Wrist and ankle acupuncture can effectively reduce the dosage of Propofol, reduce adverse reactions and shorten the recovery time in painless gastroscopy of Propofol.