番泻叶、聚乙二醇和二甲基硅油联合应用对胶囊内镜检查可见度及检出率的影响

Clinical effects of combination of senna, Polyethylene glycol and simethicone on the visibility and detection rate for capsules endoscopy

摘要:

探讨番泻叶、聚乙二醇和二甲基硅油联合应用对于胶囊内镜（CE）检查可见度及检出率的影响。方法?选取该院2016年6月－2018年9月拟行CE检查的患者126例，采用随机数表法分为对照组（n =62）与观察组（n =64），两组检查前禁食3 d，对照组予以聚乙二醇和二甲基硅油作为肠道准备，观察组在此基础上给予口服番泻叶。比较两组胃排空时间、小肠转运时间、胃和小肠的染色节段长度、绿色条带长度、肠道清洁程度、两组病变检出情况及不良反应发生情况。结果?两组患者胃排空时间、小肠转运时间、胃和小肠的染色节段无明显差异（P >0.05）；观察组全小肠和远端小肠绿色条带长度短于对照组，差异均有统计学意义[（5.53±2.93） vs （6.74±2.76）cm；t =2.39，P =0.019；（3.37±2.04） vs （5.56±2.13）cm；t =5.90，P =0.000]；两组近端小肠清洁程度差异无统计学意义（P >0.05），观察组远端小肠（89.06% vs 59.68%，χ2=14.35，P =0.000）和全小肠（87.50% vs 48.39%，χ2=22.23，P =0.000）清洁率明显高于对照组，差异有统计学意义；观察组病变总检出率明显高于对照组（92.18% vs 72.58%，χ2=8.40，P =0.004）；两组不良反应发生率差异无统计学意义（17.74% vs 18.75%，P >0.05）。结论?添加番泻叶可有效提高聚乙二醇和二甲基硅油对于CE的检查可见度和检出率。

Abstract:

To explore the effects of combination of senna, polyethylene glycol and simethicone on the visibility and detection rate for capsules endoscopy (CE). Methods From June 2016 to September 2018, 126 patients were selected for CE examination and divided into control group (62 cases) and observation group (64 cases) with random number table method, the two groups were all fasting for 3 d before examination, the control group was treated with polyethylene glycol and simethicone for intestinal preparation, the observation group was treated with senna on the basis of control group. The gastric emptying time, small bowel transit time, lengths of captured tissue color bar segments, greenish luminal content lengths, the degree of intestinal cleansing, the detection of lesions and the adverse reactions were compared between the two groups. Results There were no significant difference in gastric emptying time, small bowel transit time, lengths of captured tissue color bar segments between the two groups (P > 0.05), greenish luminal content lengths (5.53 ± 2.93) cm vs (6.74 ± 2.76) cm and (3.37 ± 2.04) vs (5.56 ± 2.13) cm of small intestine and distal small intestine in observation group were significantly shorter than that in control group (t = 2.30, 5.90; P = 0.019, 0.000). There was no significant difference in the degree of proximal intestinal cleansing between the two groups (P > 0.05). The cleansing of distal small intestine (89.06% vs 59.68%, χ2 = 14.35, P = 0.000) and whole small intestine (87.50% vs 48.39%, χ2 = 22.23, P = 0.000) in the observation group was significantly higher than that in the control group, the total detection rate was significantly higher in the observation group than in the control group (92.18% vs 72.58%, χ2 = 8.40, P = 0.004). There was no significant difference in the incidence of adverse reactions between the two groups (17.74% vs 18.75%, P > 0.05). Conclusion Add senna can effectively improve the visibility and detection rate for polyethylene glycol and simethicone in capsules endoscopy.