Abstract:To discuss the clinical effect of endoscopic release and modified open surgical release in treatment of carpal tunnel syndrome (CTS). Methods From June 2014 to June 2017, 52 patients with CTS were enrolled in the study, and they were randomly divided into two groups. 26 cases were treated with endoscopic release, and 26 cases were treated with modified open surgical release. The intraoperative and postoperative situations of the two groups were observed and compared. Results All the 52 patients were followed up with an average of (12.70 ± 2.50) months. The operative time, average hospitalization time, stitches removal time, recovery time and VAS score of incision of the endoscopic release group was similar with the modified open surgical release group [(15.12 ± 6.34) vs (13.35 ± 5.12) min, (3.45 ± 0.78) vs (3.61 ± 1.41) d, (6.25 ± 1.21) vs (7.12 ± 1.25) d, (21.40 ± 3.10) vs (23.20 ± 2.20) d, (2.20 ± 0.80) vs (2.30 ± 0.60) score], there were no statistically significant difference (t = 1.83, 0.87, 1.45, 1.95, 0.45, P ﹥ 0.05). Functional evaluation was conducted according to Kelly functional assessment standard. There was no statistically significant difference of the excellent rate between the two groups (93.55% vs 90.63%, χ2 = 0.00, P ﹥ 0.05). Conclusion Endoscopic release can achieve good clinical effectiveness in treatment of CTS. Although endoscopic surgery requires high technology and long learning curve, it has the advantages of less surgical trauma, faster postoperative recovery and fewer complications, which was worthy of clinical promotion.