不同剂量西甲硅油对患者胃镜检查效果的影响

Effect of different doses of Simethicone on the impact of patients undergoing gastroscopy

摘要:

探索不同剂量西甲硅油对患者胃镜检查效果的影响。方法 选取2016年8月－2017年1月于该院接受胃镜检查的246例患者为研究对象，按照随机数表法将患者平均分为A、B和C 3组，A组口服200 mg西甲硅油；B组口服400 mg西甲硅油；C组口服600 mg西甲硅油。观察并比较3组患者的电子胃镜视野清晰度、麻醉药物使用量和检查时间；比较3组患者的不良反应发生情况。结果 随着西甲硅油剂量的增加，电子胃镜视野优良率呈不断上升的趋势。C组患者胃镜视野清晰度为优的比例81.71%明显高于A组（12.20%）和B组（43.90%），差异有统计学意义（P <0.05）。C组患者胃镜视野清晰度为可、差的比例明显低于A组和B组患者，差异有统计学意义（P <0.05）。C组患者的视野优良率为96.34%明显高于A组（42.69%）和B组（85.36%），差异具有统计学意义（P <0.05）。随着西甲硅油剂量的增加，异丙酚使用量和胃镜检查用时呈逐渐下降的趋势。C组患者的异丙酚使用量（146.23±1.72）mg和胃镜检查用时（266.55± 3.27）min明显低于A组和B组，差异具有统计学意义（P <0.05）。B组患者的不良反应总发生率为2.44%明显低于A组（7.32%）和C组（17.08%），差异具有统计学意义（P <0.05）。结论 行电子胃镜检查前，口服西甲硅油能够明显减少食管和胃内的泡沫量，提高胃镜视野清晰度的同时使得麻醉药物和检查时间明显下降，且剂量越大清晰度越高，麻醉药物和检查用时也越少。但高剂量的西甲硅油会明显增加患者不良反应的发生率，因而综合各因素考虑，400 mg西甲硅油较为适合临床应用，既能提高视野清晰度又可降低不良反应发生率。

Abstract:

To explore the effects of different doses of Simethicone on the efficacy of gastroscopy examination.?Methods?246 patients who underwent gastroscopy from August 2016 to January 2017 were enrolled in the study. The patients were divided into three groups (A, B and C group, n = 82) according to the random number table method. A group with oral 200 mg of Simethicone; B group with oral administration of 400 mg of Simethicone; C group with oral administration of 600 mg of Simethicone. The visual acuity of the gastroscope, the amount of anesthetic drug and the time of examination were observed and compared in the three groups. The adverse reactions of the three groups were compared.?Results?With the increase of the dose of Simethicone, the excellent rate of visual field of electronic gastroscope is on the rise. In group C, the proportion of endoscopic visual field clarity was 81.71%, which was significantly higher than 12.20% in group A and 43.90% in group B. The data were statistically significant (P < 0.05). The C-visibility of the patients in group C was significantly lower than that in group A and B, and the data were statistically significant (P < 0.05). The excellent and good visual field of patients in group C was 96.34%, which was significantly higher than that in group A (42.69%, and 85.36% in group B). The data were statistically significant (P < 0.05). With the increase in the dose of Simethicone, the amount of Propofol used and the time of endoscopy showed a gradual decline. The amount of Propofol used in group C (146.23 ± 1.72) mg and the time of endoscopy (266.55 ± 3.27) min were significantly lower than those in group A and B. The data were statistically significant (P < 0.05). The overall incidence of adverse reactions in group B was 2.44%, which was significantly lower than that in group A and 17.08% in group C. The data were statistically significant (P < 0.05).?Conclusions?Oral Simethicone before electronic gastroscopy can significantly reduce the amount of foam in the esophagus and stomach, improve the clarity of the gastroscope, and significantly reduce the anesthetic and examination time, and the higher the dose, the higher the clarity, the anesthetic and the time of examination. The less. However, high dose of Simethicone can significantly increase the possibility of adverse reactions in patients. Therefore, considering the various factors, 400 mg Simethicone is more suitable for clinical application, which can improve the visual field clarity and reduce the incidence of adverse reactions.