Abstract:Abstract: Objective To compare DISCOPO endoscopy and McCoy laryngoscope in awake intubation in patients with difficult airway. Methods 60 patients with difficult airway who would have elective surgery were randomly divided into DISCOPO endoscopy group (Group D, n = 30) and McCoy group (Group M, n = 30). The patients in Group M got tracheal intubation by McCoy laryngoscope while the patients in Group D got tracheal intubation by DISCOPO after the topical tracheal anesthesia and Dexmedetomidine sedation. The time of Tracheal intubation, the first-time success rate of intubation, the Grading of glottis exposure, the adverse reactions related to intubation, blood pressure and heart rate during intubation period were observed and monitored. Results The time of tracheal intubation in Group D was obviously shorter than that in Group M (P < 0.05), the first-time success rate of intubation and the rate of low grading about glottal exposure in Group D were significantly higher than that in group M (P < 0.05). The incidence of complications in group D was significantly lower than that in group M (P < 0.01). The blood pressure and heart rate in group D were significantly lower than that in group M at T2 and T3 points (P < 0.01). Conclusions DISCOPO endoscope provided less intubation time, higher success rate and less complication in awake intubation in patients with difficult airway compared with McCoy laryngoscope.