加巴喷丁用于腹腔镜胆囊切除术后镇痛效果的Meta分析*

Efficacy of Gabapentin in reducing pain intensity and postoperative nausea and vomiting after laparoscopic cholecystectomy: a meta-analysis*

摘要:

摘要：目的 采用Meta分析的方法评价，加巴喷丁对减轻腹腔镜胆囊切除术（LC）后疼痛以及恶心呕吐的有效性和安全性。方法 手动检索Cochrane Library、Embase、Pubmed英文数据库以及中国生物医学文献数据库、维普数据库、万方数据库及中国知网数据库，检索时间截止至2018年2月，检索内容为加巴喷丁与空白对照组的临床对照试验（RCT），评价指标为术后12和24 h的视觉模拟评分（VAS）、吗啡消耗量以及术后恶心呕吐发生率，计量资料采用加权均数差（WMD）和95%置信区间（CI）表示，计数资料采用相对危险度（RR）和95%CI表示，应用Stata 12.0进行Meta分析。结果 共纳入9篇文献，纳入患者966例，其中加巴喷丁组484例，对照组482例。与对照组比较，加巴喷丁可以减少术后12和24 h的VAS评分和术后吗啡消耗量，且降低术后恶心呕吐的发生率，差异均有统计学意义（P <0.05）。结论 与对照组比较，加巴喷丁有较好的镇痛效果并且可以减轻LC术后恶心、呕吐的发生率。

Abstract:

Abstract: Objective To evaluate the efficacy of Gabapentin in reducing pain intensity and postoperative nausea and vomiting after laparoscopic cholecystectomy through a system review and meta-analysis. Methods All the randomized controlled trials (RCTs) about evaluating the efficacy of Gabapentin in reducing pain intensity and postoperative nausea and vomiting after laparoscopic cholecystectomy were searched on the database of Cochrane Library, PubMed, EMBASE, CBM, VIP, Wanfang data and CNKI. The cut-off time of search is February, 2018. Outcomes including VAS at 12 h and 24 h, total morphine consumption and the occurrence of postoperative nausea and vomiting. Quantitative data was expressed as weighted mean difference (WMD) and 95% confidence interval (CI) and count data was expressed as relative risk (RR) and 95%CI. Software Stata 12.0 was used for meta-analysis. Results A total of nine literatures involving 966 patients were identified. The number of Gabapentin and controls was 484 and 482 respectively. Compared with control group, Gabapentin was associated with less VAS at 12 h and 24, less total morphine consumption and the occurrence of nausea and vomiting (P < 0.05). Conclusion Compared with the controls, Gabapentin has better pain control effects and can decrease the occurrence of PONV.