Abstract: Objective To study three cases of Brunner’s gland hamartoma (BGH) and reviewed related literature. Methods Abdominal CT examination, gastroscopy and endoscopic lesion removal were performed in the three cases. HE staining and light microscopy were performed on the tissue specimens. Results After removal of the lesions under gastroscopic examination in the three cases, the diagnosis of duodenal Brunner adenoma was confirmed by pathological examination. Conclusion BCG is removed by electrocoagulation under gastroscopy. There is no postoperative complications occurred and the prognosis is good.