Abstract:Abastract: Objective To evaluate the efficacy, safety and strategies of endoscopic diagnosis and treatment for sympotomatic pancreas divisum. Methods The clinical data of 17 patients who underwent endoscopic endoscopic retrograde cholangiopancreatography retrograde cholangiopancreatography from January 2014 to December 2016 in our hospital with the diagnosis of pancreas divisum was retrospectively analyzed. Improvement of symptoms and postoperative recovery in patients were followed-up by telephone. Results Only 2 cases, finally successfully rescue-treated by using the rendezvous technology, namely combination of the endoscopic ultrasonography, and the other 17 cases were operated successfully. 1 case complicated with hemorrhage. 2 cases complicated with stent associated pancreatitis. No perforation, fever or other complications occurred. The follow-up time was (16.3 ± 9.4) months, All these patients had significantly improved abdominal pain after operation, VAS score is (2.0 ± 1.2) vs. (7.0 ± 1.8) (P < 0.05). Conclusion The endoscopic diagnosis and treatment for sympotomatic pancreas divisum is safe, effective, minimally invasive and with less complications. What’s more, it can significantly improve the clinical symptoms of patients, which is worth spreading in clinical works. According to the different clinical needs can choose MiES, MiED and EDSi. For patients of pancreas divisum, owing to the difficult cannulation and failed in the single ERCP procedure, rendezvous technology, namely combining with the endoscopic ultrasonography, can be a choise of remedial measures for diagnosis and treatment.