Abstract:Abstract: Objective To study the application and advantage of hysteroscopic cold instruments technique in treatment of intrauterine diseases. Methods Clinical data of 165 patients managed by hysteroscopic cold instruments technique using Hysteroscopy Endo-Operative System (HEOS) respectively for endometrial polyps, intrauterine adhesions, uterine septum, submucosal uterine myoma, cesarean scar pregnancy, missed abortion and other intrauterine diseases were retrospectively analyzed. The operation time, intraoperative blood loss, success rate of the operation, surgical complications and postoperative menstrual volume changes (compared to their normal menstrual volume) were recorded and analyzed to evaluate the application and advantage of the hysteroscopic cold instruments technique in surgically managements of those intrauterine abnormalities. Results The average operation time (minutes) of endometrial polyps, intrauterine adhesions, uterine septum, submucosal uterine myomas, cesarean scar pregnancies, missed abortions, intrauterine gestational remnants and IUD removal were (19.37 ± 9.08) min, (25.77 ± 11.09) min, (19.42 ± 6.80) min, (26.85 ± 9.15) min, (29.07 ± 15.35) min, (21.06 ± 7.07) min, (24.72 ± 10.72) min, (19.18 ± 8.31) min respectively. No intraoperative massive uterine bleeding, and only one case need a second surgery. 2 patients encountered intraoperative complications (1 with moderate-degree fluid overload and the other with uterine perforation). 6 patients complained of decreased menstrual volume compared to their normal menstrual volume. Conclusion HEOS using hysteroscopic cold instruments technique can surgically treat most intrauterine diseases which might otherwise employ traditional resectoscopic technique. The high surgical success rate in one setting and less injury to the endometrium demonstrate the advantage of this technique.