鼻内镜手术联合重组人碱性成纤维细胞生长因子治疗慢性鼻窦炎鼻息肉的临床观察

Clinical observation of nasal endoscopic surgery combined with recombinant human basic fibroblast growth factor in treatment of chronic sinusitis and nasal polyps

摘要:

摘要：目的 观察重组人碱性成纤维细胞生长因子（rh-bFGF）在慢性鼻窦炎鼻息肉内镜术后康复中的疗效。方法 将在该院耳鼻喉科接受鼻内镜手术治疗的192例慢性鼻窦炎鼻息肉患者按入院顺序随机分为两组，将术后未给予rh-bFGF治疗的96例患者作为对照组，术后给予rh-bFGF治疗的96例患者作为观察组。观察术后两组患者的术区黏膜完全上皮化时间和比率、临床疗效和并发症。结果 观察组患者鼻腔黏膜完全上皮化时间明显短于对照组，差异有统计学意义（P <0.01）；观察组患者在术后6个月内鼻腔黏膜完全上皮化比例明显高于对照组，差异有统计学意义（P <0.01）；观察组治疗总有效率明显高于对照组，差异有统计学意义（P <0.01）；对照组11例、观察组1例患者出现并发症。结论 鼻内镜术后应用rh-bFGF辅助治疗可以促进鼻黏膜修复，减少并发症的发生，疗效显著。

Abstract:

Abstract: Objective To observe the effect of recombinant human basic fibroblast growth factor in the rehabilitation of chronic sinusitis and nasal polyps after endoscopic surgery. Methods 192 cases of patients with chronic sinusitis and nasal polyps underwent endoscopic sinus surgery were randomly divided into 2 groups. 96 patients who were not treated with rh-bFGF were selected as control group. 96 patients treated with rh-bFGF were treated as observation group. The signs, remission time, hospitalization time, clinical efficacy, serum white blood cell count and inflammatory factors, adverse drug reactions and complications were observed between the two groups. The time and rate of complete epithelial metaplasia, clinical efficacy and complications were observed in the two groups after the operation. Results The complete epithelial time of nasal mucosa in the observation group was significantly shorter than that in the control group, and the difference was statistically significant (P < 0.01). The proportion of complete epithelial metaplasia of nasal mucosa in the observation group was significantly higher than that in the control group within 6 months after operation, and the difference was statistically significant (P < 0.01). The total effective rate of the observation group was significantly higher than that of the control group, the difference was statistically significant (P < 0.01). There were 11 cases in the control group and 1 cases in the observation group. Conclusions Adjuvant therapy with recombinant rh-bFGFafter nasal endoscopic surgery can promote the repair of nasal mucosa and reduce the occurrence of complications, and the curative effect is remarkable.