Abstract:Abstract: Objective To compare the clinical application and made a meta-analysis of single-hole and traditional laparoscopic appendectomy. Methods The study period was from January 1, 2015 to February 1, 2017. 121 patients were enrolled in the retrospective analysis. All the patients were diagnosed as acute appendicitis and underwent elective laparoscopic appendectomy. The patients who underwent single-hole appendectomy as observation group (n = 61), while the patients underwent traditional multi-laparoscopic appendectomy as control group (n = 60). The clinical effects were compared between the two groups. Results There was no significant difference between the control group and the observation group in intraoperative blood loss, gastrointestinal function recovery time and hospital stay (P > 0.05). The operation time of the observation group (75.62 ± 8.56) min was significantly longer than that of the control group (42.56 ± 6.36) min, with statistical significance (P < 0.05).The comparison of VAS score before and after operation in control group was significant different, with statistical significance, P < 0.05. The comparison of VAS score before and after operation in observation group was significant different, with statistical significance (P < 0.01). There was no significant difference in VAS score before operation between the two groups (P > 0.05). There was significant differences in VAS score after operation between the two groups (P < 0.05). There were significant differences in the complication between the two groups, with statistical significance (P < 0.05). There was no significant difference in incision infection between the two groups (P > 0.05). In the control group, 44 cases (73.33%) were satisfied in the observation group and 60 cases (98.36%) were satisfied in the observation group. The difference was statistically significant (P < 0.05). Conclusion The single-hole laparoscopic surgery for patients with acute appendicitis can be considered to reduce postoperative pain, improve patients’ satisfaction with abdominal wounds and reduce postoperative complications, which is worthy of clinical application and promotion.