腹腔镜结直肠癌根治术对结直肠癌患者细胞免疫功能、胃肠激素及预后的影响*

Impact of laparoscopic radical resection of colorectal cancer on cellular immune function, gastrointestinal hormones and prognosis in patients with colorectal cancer*

摘要:

摘要：目的 探讨腹腔镜结直肠癌根治术对结直肠癌患者细胞免疫功能、胃肠激素及预后的影响。方法 选择2016年7月－2017年10月收治的结直肠癌患者86例为研究对象，采用随机数字表法分为观察组和对照组各43例。对照组给予开腹结直肠癌根治术，观察组给予腹腔镜结直肠癌根治术，比较两组手术相关指标、细胞免疫功能、胃肠激素的变化和不良反应等情况。结果 观察组手术时间明显长于对照组，排便时间、排气时间、住院时间明显短于对照组，术中出血量明显少于对照组（t =10.67，11.22，13.58，8.56，19.52；P <0.05）；T淋巴细胞CD3+、CD4+、CD8+和CD4+/CD8+减少值均明显少于对照组（t =10.99，17.76，10.46，10.49；P <0.05）；血清胃泌素（GAS）、胃动素（MTL）减少值均明显低于对照组（t =10.31，13.73；P <0.05）；并发症发生率11.63%明显低于对照组30.23%（χ2=4.50，P <0.05）。结论 腹腔镜结直肠癌根治术有助于促进患者术后康复，降低术后并发症的发生，可能与对机体细胞免疫功能和胃肠激素影响较小等因素有关。

Abstract:

Abstract: Objective To investigate the impact of laparoscopic radical resection of colorectal cancer on cellular immune function, gastrointestinal hormones and prognosis in patients with colorectal cancer. Methods 86 patients with colorectal cancer from July 2016 to October 2017 were divided into observation group and control group, 43 cases in each group. The control group was given open radical colorectal surgery, while the observation group was given laparoscopic colorectal cancer radical surgery, the surgery-related indicators, cellular immune function, gastrointestinal hormones and adverse reactions and other indicators of the two groups were compared. Results The operation time, defecation time, exhaust time and hospitalization time of the observation group were significantly longer than patients in the control group, and the amount of bleeding during operation was significantly less than that of the control group (t = 10.67, 11.22, 13.58, 8.56, 19.52, P < 0.05); the decrease of T lymphocyte CD3+, CD4+, CD8+, CD4+/CD8+ were significantly less than that of the control group (t = 10.99, 17.76, 10.46, 10.49, P < 0.05); the decrease of serum gastrin (GAS) and motilin (MTL) were significantly lower than those in the control group (t = 10.31, 13.73, P < 0.05); the complications such as intestinal obstruction were 11.63% lower than those in the control group (χ2 = 4.50, P < 0.05). Conclusion Laparoscopic radical resection of colorectal cancer is helpful to promote postoperative rehabilitation and reduce the incidence of postoperative complications, which may be related to the body’s cellular immune function, gastrointestinal hormones and other factors.