To evaluate the effect of perioperative partial arterial oxygen pressure (PaO2) and partial pressure of carbon dioxide (PaCO2) by nasal packing versus septal suturing techniques during patients underwent septoplasty.?Method?Eighty patients with deviation of nasal septum were included in this study. The patients were allocated into two groups: packing group and suturing group. PaO2 and PaCO2 were tested on the first morning after surgery, and then compare the clinical data. The post-operative complications were observed.?Result?PaO2 and PaCO2 in suturing group were among the normal arrangement. The average PaO2 and PaCO2 were higher than that in packing group (P < 0.05). There is no significant differences in post-operative complications between the two groups. Conclusions Nasal suturing techniques during septoplasty might be a valid substitution for packing with more stable arterial oxygen pressure, smaller burden on the respiratory system and the same complication rates.