Abstract:To study the safety and efficacy of laparoscopic fundoplication and hiatal hernia repair for the gastroesophageal reflux disease with hiatal hernia in the primary hospitals. Methods Clinical data of 56 patients underwent laparoscopic fundoplication and hiatal hernia repair was analyzed retrospectively from January 2016 to January 2018. Results The operations were successfully performed in all the patients and no conversion to open surgery, the operation time ranged from 56 ~ 180 min, with an average (68.4 ± 3.6) min, and bleeding from 30 ~ 200 ml, the average was (40.3 ± 5.6) ml; no operative deaths and severe complications occurred. All the cases were followed up for 6~24 months. On the six months after surgery: the scores GERD-Q and De Meester were significantly lower than those before the operation (P < 0.05), and the resting pressure of the lower esophageal sphincter was significantly higher than those before the operation (P < 0.05). During 1~2 years after the operation, the symptoms of 48 patients were completely disappeared, and 6 patients were improved significantly, 2 cases were invalid. The X-ray barium meal examination showed no recurrent esophageal hiatus hernia and digestive tract obstruction. Conclusions In the primary hospitals, the laparoscopic fundoplication and hiatal hernia repair for the gastroesophageal reflux disease with hiatal hernia is safe and effective, the clinical effect is satisfactory.