鼻内镜手术治疗慢性鼻-鼻窦炎的疗效及对相关血清学指标的影响

Efficacy of nasal endoscopic surgery on chronic rhino-sinusitis and the level of serum markers

摘要:

摘要：目的??观察鼻内镜手术治疗慢性鼻-鼻窦炎的疗效及对相关血清学指标水平的影响。方法?选取该院耳鼻喉科收治确诊的慢性鼻-鼻窦炎患者172例作为研究对象，随机分为观察组（86例）与对照组（86例）。观察组研究对象予以鼻内镜手术治疗，对照组研究对象予以非手术治疗。采用视觉模拟评分（VAS）及Lund-Kennedy内镜评分评价鼻内镜手术的疗效，采用酶联免疫吸附法（ELISA）测定白细胞介素-5 （IL-5）、白细胞介素-12（IL-12）、白细胞介素-17（IL-17）、肿瘤坏死因子-α（TNF-α）、高迁移率族蛋白-1（HMGB1）和人类软骨糖蛋白39（HCGP-39）水平。结果?治疗前两组研究对象VAS评分及Lund-Kennedy评分相比差异无统计学意义（P?>0.05），治疗1和3个月后观察组VAS评分及Lund-Kennedy评分低于对照组，两组研究对象VAS评分及Lund-Kennedy评分相比差异有统计学意义（P?<0.05）。两组研究对象治疗前IL-5、IL-12、IL-17、TNF-α、HMGB1及HCGP-39水平相比差异无统计学意义（P?>0.05）。两组研究对象治疗后IL-5、IL-12、IL-17、TNF-α、HMGB1及HCGP-39水平均较治疗前有所降低，且治疗后观察组IL-5、IL-12、IL-17、TNF-α、HMGB1及HCGP-39水平均较对照组低，差异有统计学意义（P?<0.05）。结论?鼻内镜手术治疗慢性鼻-鼻窦炎临床疗效确切，且能有效降低患者血清IL-5、IL-12、IL-17、TNF-α、HMGB1及HCGP-39水平。

Abstract:

Abstract: Objective?To observe the efficacy of nasal endoscopic surgery on chronic rhino-sinusitis and the level of serum markers.?Methods?172 cases diagnosed as chronic rhino-sinusitis were divided into observation group (86 cases) and a contrast group (86 cases) randomly. The observation group were treated by nasal endoscopic surgery, the control group were treated by nonoperative treatment. The effects of treatment of nasal endoscopic surgery were measured by VAS scores and Lund-Kennedy endoscopic scores. The serum levels of IL-5, IL-12, IL-17, TNF-α, HMGB1 and HCGP-39 were measured by ELISA method.?Results?The difference was not statistically significant (P?>?0.05) between the two groups of VAS scores and Lund-Kennedy endoscopic scores before beginning therapy. The difference was statistically significant (P??0.05) between the two groups of the levels of IL-5, IL-12, IL-17, TNF-α, HMGB1 and HCGP-39 before beginning therapy. The difference was statistically significant (P?