Abstract:Abstract: Objective?To investigate the clinical efficacy and safety of real-time ultrasonography-guided ultra-mini percutaneous nephrolithotomy (UMP) using SonixGPS navigation in treatment of lower caliceal calculi without hydronephrosis.?Methods?From January 2017 to September 2017, 23 cases of lower caliceal calculi without hydronephrosis were treated with UMP under real-time ultrasonography-guided by SonixGPS navigation. 17 cases among them were single stone, while the other 6 cases were multiple renal stones. The mean stone size is (18.3?±?3.6)?mm in diameter, CT value (1253.6?±?182.8)?Hu.?Results?Single-access UMP punctured via lower caliceal was performed in all the 23 cases successfully. The mean puncture time was (4.2?±?1.6)?min; mean operation time was (42.3?±?7.6)?min; mean postoperative hospital stay was (2.6?±?0.5)?d; mean hemoglobin drop was (11.2?±?5.1)?g/L. No major complications were recorded and no analgesic consumption perioperatively. The stone clearance rate was 95.65% (22/23).?Conclusion?Real-time ultrasonography-guided UMP using SonixGPS navigation for the treatment of lower caliceal calculi without hydronephrosis is safe and effective, with high stone free rate and easy recovery, which can be popularized in clinical practice.